Article
Notch signaling in development and disease.
Clinical genetics - 1 Dec 2003
Harper J A, Yuan J S, Tan J B, Visan I, Guidos C J
Abstract excerpt
Notch receptors and ligands were first identified in flies and worms, where they were shown to regulate cell proliferation, cell differentiation, and, in particular, binary cell fate decisions in a variety of developmental contexts. The first mammalian Notch homolog was discovered to be a partner in a chromosomal translocation in a subset of human T-cell leukemias. Subsequent studies in mice and humans have shown...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.