Article
Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers.
Cancer letters - 1 Mar 2013
Kim Jeong Goo, Takeshima Hideyuki, Niwa Tohru, Rehnberg Emil, Shigematsu Yasuyuki, Yoda Yukie, Yamashita Satoshi, Kushima Ryoji, Maekita Takao, Ichinose Masao, Katai Hitoshi, Park Won Sang, Hong Young Seon, Park Cho Hyun, Ushijima Toshikazu
Abstract excerpt
Recent development of personal sequencers for extensive mutation analysis and bead array technology for comprehensive DNA methylation analysis have made it possible to obtain integrated pictures of genetic and epigenetic alterations on the same set of cancer samples. Here, we aimed to establish such pictures of gastric cancers (GCs). Comprehensive methylation analysis of 30 GCs revealed that the number of...
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