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Article

Methylation subtypes and large-scale epigenetic alterations in gastric cancer.

Science translational medicine - 17 Oct 2012

Zouridis Hermioni, Deng Niantao, Ivanova Tatiana, Zhu Yansong, Wong Bernice, Huang Dan, Wu Yong Hui, Wu Yingting, Tan Iain Beehuat, Liem Natalia, Gopalakrishnan Veena, Luo Qin, Wu Jeanie, Lee Minghui, Yong Wei Peng, Goh Liang Kee, Teh Bin Tean, Rozen Steve, Tan Patrick

Abstract excerpt

Epigenetic alterations are fundamental hallmarks of cancer genomes. We surveyed the landscape of DNA methylation alterations in gastric cancer by analyzing genome-wide CG dinucleotide (CpG) methylation profiles of 240 gastric cancers (203 tumors and 37 cell lines) and 94 matched normal gastric tissues. Cancer-specific epigenetic alterations were observed in 44% of CpGs, comprising both tumor hyper- and...

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PMID: 23076357
DOI: 10.1126/scitranslmed.3004504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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