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DNA Methylation and Genetic Aberrations in Gastric Cancer

16 Oct 2020

Abstract excerpt

BACKGROUND: Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. GC is a pathologically and molecularly heterogeneous disease. DNA hypermethylation in promoter CpG islands causes silencing of tumor-suppressor genes and thus contributes to gastric carcinogenesis. In addition, various molecular aberrations, including aberrant chromatin structures, gene mutations, structural variants,...

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PMID: 33070127
DOI: 10.1159/000511243

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