Article
Circulating αKlotho influences phosphate handling by controlling FGF23 production.
The Journal of clinical investigation - 1 Dec 2012
Smith Rosamund C, O'Bryan Linda M, Farrow Emily G, Summers Lelia J, Clinkenbeard Erica L, Roberts Jessica L, Cass Taryn A, Saha Joy, Broderick Carol, Ma Y Linda, Zeng Qing Qiang, Kharitonenkov Alexei, Wilson Jonathan M, Guo Qianxu, Sun Haijun, Allen Matthew R, Burr David B, Breyer Matthew D, White Kenneth E
Abstract excerpt
The FGF23 coreceptor αKlotho (αKL) is expressed as a membrane-bound protein (mKL) that forms heteromeric complexes with FGF receptors (FGFRs) to initiate intracellular signaling. It also circulates as an endoproteolytic cleavage product of mKL (cKL). Previously, a patient with increased plasma cKL as the result of a translocation [t(9;13)] in the αKLOTHO (KL) gene presented with rickets and a complex endocrine...
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