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Article

Altered renal FGF23-mediated activity involving MAPK and Wnt: effects of the Hyp mutation.

The Journal of endocrinology - 1 Oct 2010

Farrow Emily G, Summers Lelia J, Schiavi Susan C, McCormick James A, Ellison David H, White Kenneth E

Abstract excerpt

Fibroblast growth factor-23 (FGF23), a hormone central to renal phosphate handling, is elevated in multiple hypophosphatemic disorders. Initial FGF23-dependent Erk1/2 activity in the kidney localizes to the distal convoluted tubule (DCT) with the co-receptor α-Klotho (KL), distinct from Npt2a in proximal tubules (PT). The Hyp mouse model of X-linked hypophosphatemic rickets (XLH) is characterized by...

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Source

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Identifiers

PMID: 20675303
DOI: 10.1677/JOE-10-0181
PMCID: PMC3050595

Genes

FGF23
DCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Altered renal FGF23-mediated activity involving MAPK and Wnt: effects of the Hyp mutation.PMID 20675303Read ↗

Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO.Semantic proximity Read ↗

Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype.Semantic proximity Read ↗

Chronically elevated FGF23 drives sustained renal ERK signaling and inflammatory transcriptional programs mitigated by cFGF23 gene therapySemantic proximity Read ↗

Dynamic Single Cell Transcriptomics Defines Kidney FGF23/KL Bioactivity and Novel Segment-Specific Inflammatory TargetsSemantic proximity Read ↗

Increased bone volume and correction of HYP mouse hypophosphatemia in the Klotho/HYP mouse.Semantic proximity Read ↗

Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice.Semantic proximity Read ↗

Central role of the proximal tubular αKlotho/FGF receptor complex in FGF23-regulated phosphate and vitamin D metabolism.Semantic proximity Read ↗

In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis.Semantic proximity Read ↗

Mineralizing enthesopathy is a common feature of renal phosphate-wasting disorders attributed to FGF23 and is exacerbated by standard therapy in hyp mice.Semantic proximity Read ↗

The FGF23/KLOTHO Regulatory Network and Its Roles in Human Disorders.Semantic proximity Read ↗

Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis.Semantic proximity Read ↗

A Phex mutation in a murine model of X-linked hypophosphatemia alters phosphate responsiveness of bone cells.Semantic proximity Read ↗

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