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Article

Increased bone volume and correction of HYP mouse hypophosphatemia in the Klotho/HYP mouse.

Endocrinology - 1 Feb 2010

Brownstein Catherine A, Zhang Junhui, Stillman Althea, Ellis Bruce, Troiano Nancy, Adams Douglas J, Gundberg Caren M, Lifton Richard P, Carpenter Thomas O

Abstract excerpt

Inactivating mutations of PHEX cause X-linked hypophosphatemia and result in increased circulating fibroblast growth factor 23 (FGF23). FGF23 action is dependent upon Klotho, which converts FGF receptor 1 into an FGF23-specific receptor. Disruption of Klotho results in a complex bone phenotype an...

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Share to Familial Hypophosphatemic Rickets
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19952276
DOI: 10.1210/en.2009-0564
PMCID: PMC2817612

Genes

FGF23
PHEX
PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19952276-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased bone volume and correction of HYP mouse hypophosphatemia in the Klotho/HYP mouse.PMID 19952276Read ↗

In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis.Semantic proximity Read ↗

Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO.Semantic proximity Read ↗

Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice.Semantic proximity Read ↗

Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype.Semantic proximity Read ↗

Altered renal FGF23-mediated activity involving MAPK and Wnt: effects of the Hyp mutation.Semantic proximity Read ↗

Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice.Semantic proximity Read ↗

The FGF23/KLOTHO Regulatory Network and Its Roles in Human Disorders.Semantic proximity Read ↗

Circulating αKlotho influences phosphate handling by controlling FGF23 production.Semantic proximity Read ↗

A Phex mutation in a murine model of X-linked hypophosphatemia alters phosphate responsiveness of bone cells.Semantic proximity Read ↗

Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice.Semantic proximity Read ↗

Klotho Lacks an FGF23-Independent Role in Mineral Homeostasis.Semantic proximity Read ↗

Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis.Semantic proximity Read ↗

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