Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The T h2 cytokine, interleukin‐4, abrogates the cohesion of normal stratum corneum in mice: implications for pathogenesis of atopic dermatitis

4 Oct 2012

Abstract excerpt

There is mounting evidence that Th2 cytokines adversely affect skin barrier functions and contribute to the pathogenesis of atopic dermatitis (AD). AD is also characterized by abnormal cohesion in the stratum corneum (SC). However, the contribution of Th2 cytokines to this abnormality remains unknown. This study examined the effects of IL-4, a prototypic Th2 cytokine, on the cohesion of the SC. Structural and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allergic Rhinitis and Sensitization
Share to Contact Dermatitis and Allergies
Share to Dermatology and Skin Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23173934
DOI: 10.1111/exd.12047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The T h2 cytokine, interleukin‐4, abrogates the cohesion of normal stratum corneum in mice: implications for pathogenesis of atopic dermatitisPMID 23173934Read ↗

Therapeutic Implications of a Barrier-based Pathogenesis of Atopic DermatitisSemantic proximity Read ↗

IL-1β induces thymic stromal lymphopoietin and an atopic dermatitis-like phenotype in reconstructed healthy human epidermis.Semantic proximity Read ↗

Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8Semantic proximity Read ↗

Periostin contributes to the pathogenesis of atopic dermatitis by inducing TSLP production from keratinocytes.Semantic proximity Read ↗

Junctions and Inflammation in the SkinSemantic proximity Read ↗

Dissecting the formation, structure and barrier function of the stratum corneumSemantic proximity Read ↗

Immune-mediated Skin Inflammation is Similar in Severe Atopic Dermatitis Patients With or Without Filaggrin Mutation.Semantic proximity Read ↗

Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17Semantic proximity Read ↗

Abnormal interactions between perifollicular mast cells and CD8+ T-cells may contribute to the pathogenesis of alopecia areata.Semantic proximity Read ↗

The stratum corneum: the rampart of the mammalian bodySemantic proximity Read ↗

Mechanisms Causing Loss of Keratinocyte Cohesion in PemphigusSemantic proximity Read ↗

Increased skin barrier disruption by sodium lauryl sulfate in mice expressing a constitutively active STAT6 in T cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.