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Dissecting the formation, structure and barrier function of the stratum corneum

26 Mar 2015

Abstract excerpt

The skin is the largest organ of the mammalian body. The outermost layer of mammalian skin, the stratum corneum (SC) of the epidermis, consists of piles of dead corneocytes that are the end-products of terminal differentiation of epidermal keratinocytes. The SC performs a crucial barrier function of epidermis. Langerhans cells, when activated, extend their dendrites through tight junctions just beneath the SC to...

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PMID: 25813515
DOI: 10.1093/intimm/dxv013

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