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Article

Abnormal interactions between perifollicular mast cells and CD8+ T-cells may contribute to the pathogenesis of alopecia areata.

PloS one - 1 Jan 2014

Bertolini Marta, Zilio Federica, Rossi Alfredo, Kleditzsch Patrick, Emelianov Vladimir E, Gilhar Amos, Keren Aviad, Meyer Katja C, Wang Eddy, Funk Wolfgang, McElwee Kevin, Paus Ralf

Abstract excerpt

Alopecia areata (AA) is a CD8+ T-cell dependent autoimmune disease of the hair follicle (HF) in which the collapse of HF immune privilege (IP) plays a key role. Mast cells (MCs) are crucial immunomodulatory cells implicated in the regulation of T cell-dependent immunity, IP, and hair growth. Therefore, we explored the role of MCs in AA pathogenesis, focusing on MC interactions with CD8+ T-cells in vivo, in both...

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PMID: 24832234
DOI: 10.1371/journal.pone.0094260
PMCID: PMC4022513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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