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Article

Periostin contributes to the pathogenesis of atopic dermatitis by inducing TSLP production from keratinocytes.

Allergology international : official journal of the Japanese Society of Allergology - 1 Dec 2012

Shiraishi Hiroshi, Masuoka Miho, Ohta Shoichiro, Suzuki Shoichi, Arima Kazuhiko, Taniguchi Kazuto, Aoki Shigehisa, Toda Shuji, Yoshimoto Tomohiro, Inagaki Naoki, Conway Simon J, Narisawa Yutaka, Izuhara Kenji

Abstract excerpt

BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease where Th2-type immune responses are dominant. Keratinocytes persistently secrete proinflammatory cytokines and chemokines, amplifying Th2-type responses in AD. We have recently reported that periostin, an extracellular matrix protein induced by Th2 cytokines, plays a critical role in AD. In the present study, we have further investigated...

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Share to Antigens, Dermatophagoides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22918211
DOI: 10.2332/allergolint.10-OA-0297

Genes

TSLP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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