Article
Increased skin barrier disruption by sodium lauryl sulfate in mice expressing a constitutively active STAT6 in T cells.
Archives of dermatological research - 1 Jan 2012
DaSilva Sonia C, Sahu Ravi P, Konger Raymond L, Perkins Susan M, Kaplan Mark H, Travers Jeffrey B
Abstract excerpt
Atopic dermatitis (AD) is a pruritic, chronic inflammatory skin disease that affects 10-20% of children and 1-3% of adults worldwide. Recent studies have indicated that the ability of Th2 cytokines, such as interleukin-4 (IL-4) to regulate skin barrier function may be a predisposing factor for AD development. The present studies examined the ability of increased Th2 activity to affect cutaneous barrier function...
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