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Article

Therapeutic Implications of a Barrier-based Pathogenesis of Atopic Dermatitis

1 Jan 2010

Abstract excerpt

In this review, I first provide relevant background information about normal epidermal barrier structure and function. I then update recent information about how inherited defects in either filaggrin and/or in the serine protease inhibitor, lymphoepithelial Kazal-type inhibitor 1, converge to stimulate the development of atopic dermatitis (AD). Next I explain the multiple mechanisms whereby a primary barrier...

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PMID: 20711259
DOI: 10.5021/ad.2010.22.3.245

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