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Article

NLRP3 (rs10754558) gene polymorphism and tumor necrosis factor alpha as predictors for disease activity and response to methotrexate and adalimumab in psoriasis.

BMC immunology - 4 Jul 2024

Kamel Fatma Z, Hoseiny Heba Allah Mohamed, Shahawy Aya A El, Boghdadi Ghada, Shahawy Alia A El

Abstract excerpt

BACKGROUND: Psoriasis has a global prevalence of 1-3%, with variations observed across different ethnic groups and geographical areas. Disease susceptibility and response to anti-tumor necrosis factor-α (TNFα) drugs suggest different genetic regulatory mechanisms which may include NLR family pyrin domain containing 3 (NLRP3) polymorphism. Evaluation of the NLRP3 gene polymorphism, the serum level of CRP and TNFα...

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Source

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Identifiers

PMID: 38965465
DOI: 10.1186/s12865-024-00630-2
PMCID: PMC11223426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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