Article
Exon capture and bulk segregant analysis: rapid discovery of causative mutations using high-throughput sequencing.
BMC genomics - 21 Nov 2012
del Viso Florencia, Bhattacharya Dipankan, Kong Yong, Gilchrist Michael J, Khokha Mustafa K
Abstract excerpt
BACKGROUND: Exome sequencing has transformed human genetic analysis and may do the same for other vertebrate model systems. However, a major challenge is sifting through the large number of sequence variants to identify the causative mutation for a given phenotype. In models like Xenopus tropicalis, an incomplete and occasionally incorrect genome assembly compounds this problem. To facilitate cloning of X....
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