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Article

Modelling human genetic disorders in Xenopus tropicalis.

Disease models & mechanisms - 1 May 2024

Willsey Helen Rankin, Seaby Eleanor G, Godwin Annie, Ennis Sarah, Guille Matthew, Grainger Robert M

Abstract excerpt

Recent progress in human disease genetics is leading to rapid advances in understanding pathobiological mechanisms. However, the sheer number of risk-conveying genetic variants being identified demands in vivo model systems that are amenable to functional analyses at scale. Here we provide a practical guide for using the diploid frog species Xenopus tropicalis to study many genes and variants to uncover conserved...

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Identifiers

PMID: 38832520
DOI: 10.1242/dmm.050754
PMCID: PMC11179720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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