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Article

Using next-generation sequencing to isolate mutant genes from forward genetic screens.

Nature reviews. Genetics - 1 Oct 2014

Schneeberger Korbinian

Abstract excerpt

The long-lasting success of forward genetic screens relies on the simple molecular basis of the characterized phenotypes, which are typically caused by mutations in single genes. Mapping the location of causal mutations using genetic crosses has traditionally been a complex, multistep procedure, but next-generation sequencing now allows the rapid identification of causal mutations at single-nucleotide resolution...

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PMID: 25139187
DOI: 10.1038/nrg3745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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