Article
SHOREmap v3.0: fast and accurate identification of causal mutations from forward genetic screens.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015
Sun Hequan, Schneeberger Korbinian
Abstract excerpt
Whole-genome resequencing of pools of recombinant mutant genomes allows direct linking of phenotypic traits to causal mutations. Such analysis, called mapping-by-sequencing, combines classical genetic mapping and next-generation sequencing by relying on selection-induced patterns within genome-wide allele frequency (AF) in pooled genomes. Mapping-by-sequencing can be performed with computational tools such as...
Topics
- Crosses, Genetic
- Gene Frequency
- Genetic Testing
- Genomics
- High-Throughput Nucleotide Sequencing
- Internet
- Mutation
- Polymorphism, Single Nucleotide
- Software