Article
Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations.
PLoS genetics - 1 Jan 2012
Greaves Laura C, Elson Joanna L, Nooteboom Marco, Grady John P, Taylor Geoffrey A, Taylor Robert W, Mathers John C, Kirkwood Thomas B L, Turnbull Doug M
Abstract excerpt
Human ageing has been predicted to be caused by the accumulation of molecular damage in cells and tissues. Somatic mitochondrial DNA (mtDNA) mutations have been documented in a number of ageing tissues and have been shown to be associated with cellular mitochondrial dysfunction. It is unknown whether there are selective constraints, which have been shown to occur in the germline, on the occurrence and expansion...
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