Article

Are mitochondrial DNA mutations under purifying selection in somatic tissues?

2025-10-30

Abstract excerpt

The extent to which somatic mitochondrial DNA (mtDNA) mutations are subject to selection is a fundamental question relevant to development, mitochondrial disease, cancer, and aging. Recently a study from the Sudmant laboratory that used an advanced, high fidelity mutational analysis reported that somatic mutations in protein-coding genes exhibit signatures of negative selection. This report came as surprise as sev...

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Literature Corpus work: 7a2fa57f-14a0-57ff-a529-43988378b540
DOI: 10.1101/2025.10.26.684677

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