Article
Quantification of mitochondrial DNA mutation load.
Aging cell - 1 Sept 2009
Greaves Laura C, Beadle Nina E, Taylor Geoffrey A, Commane Daniel, Mathers John C, Khrapko Konstantin, Turnbull Doug M
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations are an important cause of genetic disease and have been proposed to play a role in the ageing process. Quantification of total mtDNA mutation load in ageing tissues is difficult as mutational events are rare in a background of wild-type molecules, and detection of individual mutated molecules is beyond the sensitivity of most sequencing based techniques. The methods currently...
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