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Article

Investigation of the BRAF V600E mutation by pyrosequencing in lymphoproliferative disorders.

American journal of clinical pathology - 1 Dec 2012

Laurini Javier A, Aoun Patricia, Iqbal Javeed, Chan Wing, Greiner Timothy C

Abstract excerpt

The presence of the BRAF c.1799T>A V600E mutation was recently described in cases of hairy cell leukemia (HCL) but not in other common lymphomas. However, many uncommon subtypes of lymphoma have not been studied. We designed a BRAF pyrosequencing assay specific for the V600E mutation, which has a sensitivity of 5% and is applicable to paraffin-embedded tissue. DNA was sequenced in 9 cases of HCL; 6 cases of...

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Share to Aged, 80 and over
Share to DNA, Neoplasm
Share to Leukemia, Hairy Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoproliferative Disorders

Share to Point Mutation

Share to Proto-Oncogene Proteins B-raf

Share to Sensitivity and Specificity

Share to Young Adult

Source

Identifiers

PMID: 23161722
DOI: 10.1309/AJCP5TWORA0TMXGL

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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