Article
Hematopoietic stem cell origin of BRAFV600E mutations in hairy cell leukemia.
Science translational medicine - 28 May 2014
Chung Stephen S, Kim Eunhee, Park Jae H, Chung Young Rock, Lito Piro, Teruya-Feldstein Julie, Hu Wenhuo, Beguelin Wendy, Monette Sebastien, Duy Cihangir, Rampal Raajit, Telis Leon, Patel Minal, Kim Min Kyung, Huberman Kety, Bouvier Nancy, Berger Michael F, Melnick Ari M, Rosen Neal, Tallman Martin S, Park Christopher Y, Abdel-Wahab Omar
Abstract excerpt
Hairy cell leukemia (HCL) is a chronic lymphoproliferative disorder characterized by somatic BRAFV600E mutations. The malignant cell in HCL has immunophenotypic features of a mature B cell, but no normal counterpart along the continuum of developing B lymphocytes has been delineated as the cell of origin. We find that the BRAFV600E mutation is present in hematopoietic stem cells (HSCs) in HCL patients, and that...
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