Article
BRAF mutations in hairy-cell leukemia.
The New England journal of medicine - 16 Jun 2011
Tiacci Enrico, Trifonov Vladimir, Schiavoni Gianluca, Holmes Antony, Kern Wolfgang, Martelli Maria Paola, Pucciarini Alessandra, Bigerna Barbara, Pacini Roberta, Wells Victoria A, Sportoletti Paolo, Pettirossi Valentina, Mannucci Roberta, Elliott Oliver, Liso Arcangelo, Ambrosetti Achille, Pulsoni Alessandro, Forconi Francesco, Trentin Livio, Semenzato Gianpietro, Inghirami Giorgio, Capponi Monia, Di Raimondo Francesco, Patti Caterina, Arcaini Luca, Musto Pellegrino, Pileri Stefano, Haferlach Claudia, Schnittger Susanne, Pizzolo Giovanni, Foà Robin, Farinelli Laurent, Haferlach Torsten, Pasqualucci Laura, Rabadan Raul, Falini Brunangelo
Abstract excerpt
BACKGROUND: Hairy-cell leukemia (HCL) is a well-defined clinicopathological entity whose underlying genetic lesion is still obscure. METHODS: We searched for HCL-associated mutations by performing massively parallel sequencing of the whole exome of leukemic and matched normal cells purified from the peripheral blood of an index patient with HCL. Findings were validated by Sanger sequencing in 47 additional...
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