Article
Identification of the BRAF V600E mutation in Japanese patients with hairy cell leukemia and related diseases using a quenching probe method.
International journal of hematology - 1 Oct 2018
Itamura Hidekazu, Ide Masaru, Sato Akemi, Sueoka-Aragane Naoko, Sueoka Eisaburo, Nishida Aya, Masunari Taro, Aoki Sadao, Takizawa Jun, Suzumiya Junji, Kimura Shinya
Abstract excerpt
Hairy cell leukemia (HCL) is a rare B-cell lymphoid malignancy that is difficult to distinguish from other morphological variants. The frequency of HCL has not been determined accurately in Japan. Recent studies revealed that the BRAF V600E mutation is the causal genetic event in HCL. We assessed the BRAF mutation in Japanese patients with HCL and related diseases using the quenching probe (QP) method, a...
Topics
- Adult
- Aged
- Aged, 80 and over
- Amino Acid Substitution
- Asian People
- Female
- Humans
- Japan
- Leukemia, Hairy Cell
- Male
- Middle Aged