Pyrosequencing of BRAF V600E in routine samples of Hairy Cell Leukaemia identifies CD5+ variant Hairy Cell Leukaemia that lacks V600E

Abstract excerpt

Recently, Tiacci et al (2011) documented for the first time that 100% of hairy-cell leukaemia (HCL) carry the BRAF-V600E mutation (Tiacci et al, 2011). Given the extraordinarily high frequency along with potential treatment implications (Cantwell-Dorris et al, 2011), there is an implicit understanding that BRAF testing could be part of the laboratory diagnosis of HCL (Takahashi et al, 2011; Tiacci et al, 2011)....

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