Immunohistochemical analysis using a BRAF V600E mutation specific antibody is highly sensitive and specific for the diagnosis of hairy cell leukemia.

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Article

Immunohistochemical analysis using a BRAF V600E mutation specific antibody is highly sensitive and specific for the diagnosis of hairy cell leukemia.

International journal of clinical and experimental pathology - 1 Jan 2014

Wang Xuan J, Kim Annette, Li Shaoying

Abstract excerpt

Hairy cell leukemia (HCL) is usually diagnosed by morphology and flow cytometry studies. However, it is challenging sometimes to distinguish HCL from its mimics. Recently, the BRAF V600E mutation has been described as a disease-defining molecular marker for HCL which is present in nearly all case...

Topics

Antibodies, Monoclonal
Humans
Immunohistochemistry
Leukemia, Hairy Cell
Mutation
Proto-Oncogene Proteins B-raf
Sensitivity and Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 25120816
PMCID: PMC4129051

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-25120816-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

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Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.