Article
Association of Mineralocorticoid Receptor Polymorphism I180V With Left Ventricular Hypertrophy in Resistant Hypertension.
American journal of hypertension - 1 Feb 2016
Ritter Alessandra Mileni Versuti, Fontana Vanessa, Faria Ana Paula Cabral de, Modolo Rodrigo, Barbaro Natália R, Sabbatini Andréa R, Peres Heverton, Biagi Celso, Silva Pamela S, Lopes Paulo C, Tanus-Santos José Eduardo, Coelho Eduardo B, Moreno Heitor
Abstract excerpt
OBJECTIVES: Genetic polymorphisms on mineralocorticoid receptor gene (NC3C2) are associated with variability of mineralocorticoid receptor (MR) function and cardiovascular implications. We sought to investigate whether I180V (rs5522) and MRc.-2G_C (rs2070951) polymorphisms in NR3C2 gene are associated with resistance to antihypertensive treatment and target-organ damage in resistant hypertensive (RHTN) patients....
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