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Article

Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age.

Experimental gerontology - 1 Feb 2013

Sikka Gautam, Miller Karen L, Steppan Jochen, Pandey Deepesh, Jung Sung M, Fraser Charles D, Ellis Carla, Ross Daniel, Vandegaer Koenraad, Bedja Djahida, Gabrielson Kathleen, Walston Jeremy D, Berkowitz Dan E, Barouch Lili A

Abstract excerpt

UNLABELLED: Cardiovascular dysfunction is a primary independent predictor of age-related morbidity and mortality. Frailty is associated with activation of inflammatory pathways and fatigue that commonly presents and progresses with age. Interleukin 10 (IL-10), the cytokine synthesis inhibitory factor, is an anti-inflammatory cytokine produced by immune and non-immune cells. Homozygous deletion of IL-10 in mice...

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Identifiers

PMID: 23159957
DOI: 10.1016/j.exger.2012.11.001
PMCID: PMC3744178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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