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Article

Inflammation and mortality in a frail mouse model.

Age (Dordrecht, Netherlands) - 1 Jun 2012

Ko Fred, Yu Qilu, Xue Qian-Li, Yao Wenliang, Brayton Cory, Yang Huanle, Fedarko Neal, Walston Jeremy

Abstract excerpt

Mice homozygous for targeted deletion of the interleukin 10 gene (Il-10) have been partially characterized as a model for human frailty. These mice have increased serum interleukin (IL)-6 in midlife, skeletal muscle weakness, and an altered skeletal muscle gene expression profile compared to age and sex-matched C57BL/6 (B6) control mice. In order to further characterize for use as a frailty model, we evaluated...

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Identifiers

PMID: 21633802
DOI: 10.1007/s11357-011-9269-6
PMCID: PMC3337927

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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