Article
Aerobic exercise reverses arterial inflammation with aging in mice.
American journal of physiology. Heart and circulatory physiology - 1 Sept 2011
Lesniewski Lisa A, Durrant Jessica R, Connell Melanie L, Henson Grant D, Black Alexander D, Donato Anthony J, Seals Douglas R
Abstract excerpt
We tested the hypothesis that regular aerobic exercise reverses arterial inflammation with aging. When compared with young controls (6.2 ± 0.4 mo; n = 7), old (31.3 ± 0.5 mo; n = 11) male B6D2F1 cage-restricted mice demonstrated increased arterial activation of the proinflammatory transcription factor NF-κB, as indicated by greater aortic phosphorylation of both the inhibitor of NF-κB kinase (IKK) and the p65...
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