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Article

Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice.

Molecular medicine (Cambridge, Mass.) - 1 Jan 2000

Caligiuri Giuseppina, Rudling Mats, Ollivier Véronique, Jacob Marie-Paule, Michel Jean-Baptiste, Hansson Göran K, Nicoletti Antonino

Abstract excerpt

Interleukin (IL)-10 is an anti-inflammatory cytokine that may play a protective role in atherosclerosis. The aim of this study was to assess the effect of IL-10 deficiency in the apolipoprotein E knockout mouse. Apolipoprotein E deficient (E-/-) and IL-10 deficient (-/-) mice were crossed to gene...

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Identifiers

PMID: 12765335
PMCID: PMC1430379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12765335-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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