Article
Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of angiotensin II-infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in angiotensin-induced vascular injury.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2005
De Ciuceis Carolina, Amiri Farhad, Brassard Pascal, Endemann Dierk H, Touyz Rhian M, Schiffrin Ernesto L
Abstract excerpt
OBJECTIVE: Angiotensin (Ang) II-induced vascular damage may be partially mediated by reactive oxygen species generation and inflammation. Homozygous osteopetrotic mice (Op/Op), deficient in macrophage colony-stimulating factor (m-CSF), exhibit reduced inflammation. We therefore investigated Ang II effects on vascular structure, function, and oxidant stress generation in this model. METHODS AND RESULTS: Adult...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.