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Article

Age-associated pro-inflammatory remodeling and functional phenotype in the heart and large arteries.

Journal of molecular and cellular cardiology - 1 Jun 2015

Wang Mingyi, Shah Ajay M

Abstract excerpt

The aging population is increasing dramatically. Aging-associated stress simultaneously drives proinflammatory remodeling, involving angiotensin II and other factors, in both the heart and large arteries. The structural remodeling and functional changes that occur with aging include cardiac and vascular wall stiffening, systolic hypertension and suboptimal ventricular-arterial coupling, features that are often...

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Identifiers

PMID: 25665458
DOI: 10.1016/j.yjmcc.2015.02.004
PMCID: PMC4459900

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