Article
[KRAS and BRAF gene mutations in correlation with clinicopathologic features of colorectal carcinoma in Chinese].
Zhonghua bing li xue za zhi = Chinese journal of pathology - 1 Sept 2012
Zhu Xiao-li, Cai Xu, Zhang Ling, Yang Fei, Sheng Wei-qi, Lu Yong-ming, Du Xiang, Zhou Xiao-yan
Abstract excerpt
OBJECTIVE: To retrospectively analyze KRAS and BRAF gene mutation features in Chinese colorectal cancer (CRC) and their clinicopathologic relationship. METHODS: 557 colorectal cancer cases were collected, including 325 colon cancer and 232 rectal cancer. PCR amplification and DNA sequencing were used to detect mutations in exon 2 of KRAS gene and exon 15 of BRAF gene mutation. RESULTS: (1) KRAS mutation was found...
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