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Article

Genetic elevation of sphingosine 1-phosphate suppresses dystrophic muscle phenotypes in Drosophila.

Development (Cambridge, England) - 1 Jan 2013

Pantoja Mario, Fischer Karin A, Ieronimakis Nicholas, Reyes Morayma, Ruohola-Baker Hannele

Abstract excerpt

Duchenne muscular dystrophy is a lethal genetic disease characterized by the loss of muscle integrity and function over time. Using Drosophila, we show that dystrophic muscle phenotypes can be significantly suppressed by a reduction of wunen, a homolog of lipid phosphate phosphatase 3, which in higher animals can dephosphorylate a range of phospholipids. Our suppression analyses include assessing the localization...

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Identifiers

PMID: 23154413
DOI: 10.1242/dev.087791
PMCID: PMC3513996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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