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Article

Reduction of circulating sphingosine-1-phosphate worsens mdx soleus muscle dystrophic phenotype.

Experimental physiology - 1 Nov 2020

Germinario Elena, Bondì Michela, Blaauw Bert, Betto Romeo, Danieli-Betto Daniela

Abstract excerpt

NEW FINDINGS: What is the central question of the study? What are the consequences of reducing circulating sphingosine-1-phosphate (S1P) for muscle physiology in the murine model of Duchenne muscular dystrophy (DMD)? What is the main result and its importance? Reduction of the circulating S1P level in mdx mice aggravates the dystrophic phenotype, as seen by an increase in fibre atrophy, fibrosis and loss of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32897592
DOI: 10.1113/EP088603

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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