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Article

Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy.

Disease models & mechanisms - 1 Jan 2014

Nguyen-Tran Diem-Hang, Hait Nitai C, Sperber Henrik, Qi Junlin, Fischer Karin, Ieronimakis Nick, Pantoja Mario, Hays Aislinn, Allegood Jeremy, Reyes Morayma, Spiegel Sarah, Ruohola-Baker Hannele

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a lethal muscle-wasting disease. Studies in Drosophila showed that genetic increase of the levels of the bioactive sphingolipid sphingosine-1-phosphate (S1P) or delivery of 2-acetyl-5-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, suppresses dystro...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24077965
DOI: 10.1242/dmm.013631
PMCID: PMC3882047

Genes

DMD
HDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24077965-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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