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Article

Sply regulation of sphingolipid signaling molecules is essential for Drosophila development.

Development (Cambridge, England) - 1 Jun 2003

Herr Deron R, Fyrst Henrik, Phan Van, Heinecke Karie, Georges Rana, Harris Greg L, Saba Julie D

Abstract excerpt

Sphingosine-1-phosphate is a sphingolipid metabolite that regulates cell proliferation, migration and apoptosis through specific signaling pathways. Sphingosine-1-phosphate lyase catalyzes the conversion of sphingosine-1-phosphate to ethanolamine phosphate and a fatty aldehyde. We report the cloning of the Drosophila sphingosine-1-phosphate lyase gene (Sply) and demonstrate its importance for adult muscle...

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Identifiers

PMID: 12702658
DOI: 10.1242/dev.00456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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