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Article

Sphingolipids regulate neuromuscular synapse structure and function in Drosophila.

The Journal of comparative neurology - 1 Sept 2018

West Ryan J H, Briggs Laura, Perona Fjeldstad Maria, Ribchester Richard R, Sweeney Sean T

Abstract excerpt

Sphingolipids are found in abundance at synapses and have been implicated in regulation of synapse structure, function, and degeneration. Their precise role in these processes, however, remains obscure. Serine Palmitoyl-transferase (SPT) is the first enzymatic step for synthesis of sphingolipids. Analysis of the Drosophila larval neuromuscular junction (NMJ) revealed mutations in the SPT enzyme subunit,...

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Share to Synapses
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29761896
DOI: 10.1002/cne.24466
PMCID: PMC6175220

Genes

SPTLC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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