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Potential TMA-Producing Bacteria Are Ubiquitously Found in Mammalia

9 Jan 2020

Abstract excerpt

Human gut bacteria metabolize dietary components such as choline and carnitine to trimethylamine (TMA) that is subsequently oxidised to trimethylamine-N-oxide (TMAO) by hepatic enzymes. Increased plasma levels of TMAO are associated with the development of cardiovascular and renal disease. In this study, we applied gene-targeted assays in order to quantify (qPCR) and characterize (MiSeq) bacterial genes encoding...

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Folate and B Vitamins Research
Gut microbiota and health
Metabolism and Genetic Disorders

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31998260
DOI: 10.3389/fmicb.2019.02966

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