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An Expanded Genetic Code Enables Trimethylamine Metabolism in Human Gut Bacteria

26 Oct 2020

Abstract excerpt

-oxide (TMAO) and cardiovascular disease (CVD) have focused attention on mechanisms by which animal-based diets have negative health consequences. In a meta-analysis of data from foundational gut microbiome studies, we found evidence that specialized bacteria have and express a metabolic pathway that circumvents TMAO production and is often misannotated because it relies on genetic code expansion. This naturally...

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PMID: 33109749
DOI: 10.1128/msystems.00413-20

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