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Article

Donor CYP3A5 Gene Polymorphism Alone Cannot Predict Tacrolimus Intrarenal Concentration in Renal Transplant Recipients.

International journal of molecular sciences - 23 Apr 2020

Zhang Mengyu, Tajima Soichiro, Shigematsu Tomohiro, Fu Rao, Noguchi Hiroshi, Kaku Keizo, Tsuchimoto Akihiro, Okabe Yasuhiro, Egashira Nobuaki, Masuda Satohiro

Abstract excerpt

CYP3A5 gene polymorphism in recipients plays an important role in tacrolimus blood pharmacokinetics after renal transplantation. Even though CYP3A5 protein is expressed in renal tubular cells, little is known about the influence on the tacrolimus intrarenal exposure and hence graft outcome. The aim of our study was to investigate how the tacrolimus intrarenal concentration (Ctissue) could be predicted based on...

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Identifiers

PMID: 32340188
DOI: 10.3390/ijms21082976
PMCID: PMC7215698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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