Article
Correction for population stratification in random forest analysis.
International journal of epidemiology - 1 Dec 2012
Zhao Yang, Chen Feng, Zhai Rihong, Lin Xihong, Wang Zhaoxi, Su Li, Christiani David C
Abstract excerpt
BACKGROUND: Population structure (PS), including population stratification and admixture, is a significant confounder in genome-wide association studies (GWAS), as it may produce spurious associations. Random forest (RF) has been increasingly applied in GWAS data analysis because of its advantage in analysing high dimensional genetic data. RF creates importance measures for single nucleotide polymorphisms (SNPs),...
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