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Article

Adjustment for population stratification via principal components in association analysis of rare variants.

Genetic epidemiology - 1 Jan 2013

Zhang Yiwei, Guan Weihua, Pan Wei

Abstract excerpt

For unrelated samples, principal component (PC) analysis has been established as a simple and effective approach to adjusting for population stratification in association analysis of common variants (CVs, with minor allele frequencies MAF > 5%). However, it is less clear how it would perform in analysis of low-frequency variants (LFVs, MAF between 1% and 5%), or of rare variants (RVs, MAF < 5%). Furthermore, with...

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PMID: 23065775
DOI: 10.1002/gepi.21691
PMCID: PMC4066816

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MAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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