Article
Exploiting SNP correlations within random forest for genome-wide association studies.
PloS one - 1 Jan 2014
Botta Vincent, Louppe Gilles, Geurts Pierre, Wehenkel Louis
Abstract excerpt
The primary goal of genome-wide association studies (GWAS) is to discover variants that could lead, in isolation or in combination, to a particular trait or disease. Standard approaches to GWAS, however, are usually based on univariate hypothesis tests and therefore can account neither for correlations due to linkage disequilibrium nor for combinations of several markers. To discover and leverage such potential...
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