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Article

Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants.

Antimicrobial agents and chemotherapy - 1 Jan 2013

Sun Nuo, Fonzi William, Chen Hui, She Xiaodong, Zhang Lulu, Zhang Lixin, Calderone Richard

Abstract excerpt

Mitochondrial dysfunction in pathogenic fungi or model yeast causes altered susceptibilities to antifungal drugs. Here we have characterized the role of mitochondrial complex I (CI) of Candida albicans in antifungal susceptibility. Inhibitors of CI to CV, except for CII, increased the susceptibility of both patient and lab isolates, even those with a resistance phenotype. In addition, in a C. albicans library of...

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Identifiers

PMID: 23147730
DOI: 10.1128/AAC.01520-12
PMCID: PMC3535965

Genes

CDR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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