Goa1p of <i>Candida albicans</i> Localizes to the Mitochondria during Stress and Is Required for Mitochondrial Function and Virulence

Abstract excerpt

Using a Tn7 transposon library of Candida albicans, we have identified a mutant that exhibited sensitivity in drop plate assays to oxidants such as menadione and hydrogen peroxide. To verify the role of the mutated gene in stress adaptation, null mutants were constructed and phenotypically characterized. Because of its apparent functions in growth and oxidant adaptation, we have named the gene GOA1. Goa1p appears...