Article
Enzymatic dysfunction of mitochondrial complex I of the Candida albicans goa1 mutant is associated with increased reactive oxidants and cell death.
Eukaryotic cell - 1 May 2011
Li Dongmei, Chen Hui, Florentino Abigail, Alex Deepu, Sikorski Patricia, Fonzi William A, Calderone Richard
Abstract excerpt
We have previously shown that deletion of GOA1 (growth and oxidant adaptation) of Candida albicans results in a loss of mitochondrial membrane potential, ATP synthesis, increased sensitivity to oxidants and killing by human neutrophils, and avirulence in a systemic model of candidiasis. We established that translocation of Goa1p to mitochondria occurred during peroxide stress. In this report, we show that the...
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