Article
Mitochondrial Complex I Is a Global Regulator of Secondary Metabolism, Virulence and Azole Sensitivity in Fungi.
PloS one - 1 Jan 2016
Bromley Mike, Johns Anna, Davies Emma, Fraczek Marcin, Mabey Gilsenan Jane, Kurbatova Natalya, Keays Maria, Kapushesky Misha, Gut Marta, Gut Ivo, Denning David W, Bowyer Paul
Abstract excerpt
Recent estimates of the global burden of fungal disease suggest that that their incidence has been drastically underestimated and that mortality may rival that of malaria or tuberculosis. Azoles are the principal class of antifungal drug and the only available oral treatment for fungal disease. Recent occurrence and increase in azole resistance is a major concern worldwide. Known azole resistance mechanisms...
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